Impact of Cross-Sex Hormones on Women and Girls: 09.12.25

It was a hectic day at Westminster but that didn’t stop the APPG from discussing the puberty blockers trial. Dr Alice Hodgkinson from Biology in Medicine and Stella O’Malley of the international organisation, Genspect, honed in on the very real dangers to girls and young women of puberty blockers and cross sex hormones..

APPG members were horrified to hear of the physical harms of medical intervention on female bodies. Vaginal atrophy, sexual disfunction, raised levels of osteoporosis, glaucoma, higher rates of heart disease were all discussed. Dr Hodgkinson described her shame at the thought that her profession, a profession primarily concerned with improving health, could be so key in destroying the lives of girls and young women.

Stella O’Malley’s message was that parliamentarians should do all they possibly could to acknowledge the rise in trans identified girls as a mental health crisis. These girls, she told us, are lonely and have difficulty socialising.

They have often experience family or sexual trauma. Many of them have an autistic mindset and search for a ‘one size fits all’ answer to their problems. A transgender identity, with its ready-made support network and relatable checklist of ‘symptoms’ is very attractive to girls looking for a solution.

‘Puberty blockers and cross-sex hormones are a physical treatment for a psychological problem’, Ms O’Malley explained.

The group discussed the importance for those in parliament to put the case for stopping the PB trial.